General Sheppard O'Neill is a character in Deus Ex: Human Revolution.
O'Neill was present at the Sarif Industries HQ on the night it was attacked by the Tyrants, checking the progress of the Typhoon Explosive System. Vasili Sevchenko, one of the scientists working on the project, provided him with a demonstration of an early version of the augmentation, with which O'Neill was impressed.
- O'Neill uniform has the Canadian "Land Forces Command Badge" (white badge with 2 swords going through a Maple Leaf) and also has his Parachute Qualification "Jump Badge" Wings. His Epaulettes identify him as a Brigadier General.
- In early versions of the game, Adam Jensen could hack David Sarif's computer and read an e-mail where Sarif and O'Neill discussed the concept of a "skull-gun". In Sarif's opinion it would never be viable as a mechanical augmentation. The discussion is a reference to the weapon requested by Gunther Hermann in Deus Ex, which he called a "skul-gun".
- General O'Neill may be inspired by Stargate SG-1 character, Colonel Jack O'Neill, who is later promoted to General. On the show, O'Neill often says "Thats O'Neill, with 2 Ls". His first name may also be a reference to John Sheppard, the main character of Stargate: Atlantis. Both Stargate shows were filmed in Canada.