Matt Ryan is a United States Secret Service agent and a coworker and friend of Anna Kelso. He had helped her overcome her stim addiction. He was assigned to escort Jane Skyler and Garrett Dansky during a meeting. However, he was killed by Gunther Hermann.
- He appears in Deus Ex: Icarus Effect, but is killed around the beginning.
- He is mentioned in Deus Ex: The Fall on an audio recording made by Anna Kelso in the Duarte Safehouse.