- SH-187 stealth helicopter
- SMG
- SP69/75 Aero Security Bot
- SWAT
- Sabot (damage type)
- Safe Harbour Initiative
- Sailor
- Salar Alam
- Sam Carter
- Sam Carter's computer
- Sam Carter/Development
- Sam Duarte
- Saman
- Samizdat
- Samizdat (mission)
- Samizdat computers
- Sandoval
- Sandra Renton
- Sandra Renton/Development
- Santeau - Rise of a Corpo-Nation
- Santeau Group
- Sarah Mead
- Sarif Industries
- Sarif Industries: Rising to Tomorrow
- Sarif Industries Headquarters
- Sarif Industries Incident Report
- Sarif Manufacturing Plant
- Sarif Manufacturing Plant Admin Building computers
- Sarif Manufacturing Plant lobby computers
- Sarif Series 8 Energy Converter (DXHR)
- Sarif Series 8 Energy Converter (DXMD)
- Sarifindustries.com
- Sawed-off shotgun
- Scavenger
- Scientist (DX)
- Scott
- Scott Hardesty
- Scramble grenade
- Scrambler grenade
- Scrambler prox mine
- Scrambling Device
- Scuba diver
- Sea-Tec
- Sean Murphy
- Searching for Proof
- Seattle
- Seattle Tarsus Academy
- Sebastian King
- Secret MJ12 Facility
- Secret Service
- Secret Service Agent
- Secure Neuropozyne
- Securing Sarif's Manufacturing Plant
- Securing the Convention Centre
- SecurityBot1
- SecurityBot4
- Security Bot Mark 2
- Security Computer Terminal
- Security Keypad (DX)
- Security Manager Office
- Security camera
- Security camera (DX)
- Senjin Braeden
- Senjin Braeden's journal
- Sentimental Value
- Sentinel RX Health System (DXHR)
- Sentinel RX Health System (DXMD)
- Seth Chen
- Seurat
- Seurat's computer
- ShadowChild
- ShadowChild's apartment
- Shadow Operatives
- Shadows of the Machine
- Shanghai Justice
- Shannon
- Shared conversations (Deus Ex)
- Sharp Edge
- Sheppard O'Neill
- Sherri ter Horst
- Sherri ter Horst's computer
- Shield (NPC ability)
- Shifter (Mod)
- Shirow Yoshitaka
- Shocked (damage type)
- Shooter
- Shooter: Majestic Revelations
- Shooter: Majestic Revelations design document version 5.3e
- Shooter: Majestic Revelations design document version 6.4
- Shooter design document version 3
- Shop (DXHR)
- Shorthand
- Shot (damage type)
- Shotgun
- Shotgun (DXIW)
- Shotgun Ammo (DXMD)
- Shutting Down Darrow's Signal
- Sid Black
- Side missions
- Signal Jammer
- Silas Archer
- Silencer
- Silencer (DXIW)
- Silencer (DXMD)
- Silhouette
- Silly Short Stories Volume 78
- Simon Whittaker
- Simon Whittaker's computer
- Simona Saridakis
- Singapore
- Singh No Swan Song
- Singularity Church of the MachineGod
- Skill Points
- Skills
- Skip Riley
- Skulls
- Sleight of Hand
- Slow & Sharp
- Smackdown
- Smart Vision (DXHR)
- Smart Vision (DXMD)
- Smash the State
- Smashing Entrance
- Smooth Like Soap
- Smooth Operator
- Smuggler
- Smuggler's Lair
- Smuggler's computer
- Smuggler/Development
- Sneak Peak: Mag Rail
- Sneaker
- Sniper Rifle Ammo (DXMD)
- Sniper rifle
- Sniper rifle (DX)
- Sniper rifle (DXIW)
- So Many Cucumbers
- Sobchak Security
- Sobchak Security computer
- Social Enhancer (DXHR)
- Social Enhancer (DXMD)
- Soda
- Soda (DX)
- Soda (DXIW)
- Softkey
- Soldier
- Soloto
- Sophia Sak
- Sophia Sak's Hangar
- Soy (DXIW)
- Soy food
- Space station mission
- Spec Ops Shifter
- Spec Ops Soldier
- Speed Enhancement
- Spider bot
- Spiderbomb
- Spilling the Beans
- Spirits
- Spokes in Two Wheels
- Sporting Weapons Act
- Spy Drone
- Squalnomie
- Square Enix
- Stacy Webber
- Stalkers
- Stan Carnegie
- Stana Tomasek
- Stana Tomasek's computer
- Standard Security Corporation
- Stansfield Christiansen
- Stanton Dowd
- Stanton Dowd's computer
- Stanton Dowd/Development
- Starting Off on the Right Foot
- Stasiuk Arms
- Statue of Liberty
- Stealth Avatar
- Stealth Enhancer
- Stealth Pistol
- Stealth Software
- Steamy Dinkins
- Stefa
- Steiner-Bisley GmbH
- Stem Processor Chip
- Stephanie Maxwell
- Stephen Shellen
- Stomping (DX)
- Stop! Worm Software (DXHR)
- Stop! Worm Software (DXMD)
- Stopping Marchenko
- Stopping Power
- Stopping the Transmission
- Story Items (A Criminal Past)
- Story Items (DXMD)
- Stowing Away
- Strike4
- Strike Team Six
- Stuart St. John
- Stuart St. John's computer
- Stun Gun (DXTF)
- Stun Gun Ammo (DXMD)
- Stun gun
- Stun prod
- Stunned (damage type)
- Sue Feguson
- Super Six Zero's computer
- Super Sleuth
- Supply crate
- Surprise Party
- Susan Glover
- Svobody Beer
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