The series tells a side-story of Deus Ex: Human Revolution, retaining the protagonist Adam Jensen, and taking place right after the fight with the notorious antagonist Lawrence Barrett. The comics expand on many aspects of the storyline, primarily Jensen's past as a SWAT team member and its connections to his present life. It makes for an interesting segue in the Human Revolution story, featuring many familiar faces such as David Sarif, Francis Pritchard, Dr. Marcovic, and Faridah Malik, along with a few new in-depth individuals.
- Despite the storyline within Human Revolution still being relatively undeveloped, Jensen has a surprising amount of active augmentations throughout the comic series.
- The Augmented Edition of the game contains a bonus disc that includes a video - a nine minute long 'motion comic' - that takes you through the first half of the first issue.
- Sergio Sandobal is credited in all of the comics except the first issue.
- Jorge Gonzalez is credited as the artist of color in the comics, yet DC Comics lists Rex Lokus.
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